Anaplastic lymphoma kinase (ALK) is one of the common oncogenic driver genes in non-small cell lung cancer (NSCLC).Tyrosine kinase inhibitors (TKIs) have achieved excellent therapeutic effects in patients with ALK fusion positive NSCLC.However, patients will eventually develop resistance to TKIs.Acquired molecular drug resistance mechanisms, such a
Glucosamine, monosaccharide from chitosan obtained from the chitin deacetylation process, has been used widely in various fields such as nutrition, pharmacy, and cosmetics.Glucosamine can be obtained from the hydrolysis of chitosan.Enzymatic hydrolysis provides the advantage of mild reaction conditions, environmentally friendly, and high yield.But
Analysis of the dynamics of land use and land cover change (LULCC) along rivers that supply water to settlements provides crucial information to decision-makers; it offers information for planners and water supply authorities on water management issues in general.The paper analyzed LULCC along Boteti and Thamalakane rivers and predicted the probabl
Abstract Cervical cancer is one of the deadly diseases that affects women, which requires periodic examinations to identify and treat any cancerous tumors at a preliminary stage.The most prevalent examination tool for cervical cancer prompt identification is the cervical smear (Pap smear) testing; however, due to human negligence, this examination